Abstract
Summary
Liver cells of rats starved and then refed a high-protein diet retain the cellular memory of starvation and respond to a high-carbohydrate diet by developing the enzyme overshoot. A second cycle of starvation causes an even greater overshoot and the increased capability after one starve-refeed cycle is retained during and after a second cycle. The best explanation of the data is that during refeeding the high-carbohydrate diet after starvation new RNA is formed which persists during subsequent dietary manipulations.
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