Abstract
Summary
Cellular immunity in leukemic mice was studied using Friend leukemia virus and susceptible BALB/c mice. Injection of this virus into the test mice resulted in rapid development of splenomegaly and other symptoms of leukemia. There was a concomitant decrease in the ability of peritoneal cells from these animals to respond to PPD in vitro, as assessed by the macrophage migration-inhibition procedure.
Sensitization of normal mice with mycobacteria in Freund's complete adjuvant resulted in rapid development of cellular immunity as assessed by the migration-inhibition assay. Failure to detect cellular immunity by this assay with peritoneal cells from leukemia virus-infected mice correlates with the marked decrease in humoral immunity, as well as cellular immunity previously assessed by skin graft rejection assays.
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