Abstract
Summary
The effect of insulin on the creatine content of blood and urine was studied in rats which were made creatinuric by the ip injection of creatine. The results indicate that 0.5–2.0 units of NPH insulin administered sc 2 hr prior to the injection of 5 mg of creatine prevented creatinuria induced by creatine loading. When rats were injected with 5 mg of creatine, the blood creatine concentration rose to 190% of the preinjection control value after 60 min and then fell to 180% of the control after 2 hr. The blood creatine concentration in rats treated with 2 units of insulin increased to 114% of the control value 1 hr after creatine loading and then decreased slightly after 2 hr. These results show that the hyper-creatinemia which occurs in rats shortly after creatine loading can also be suppressed by insulin, suggesting that the action of the hormone in preventing load-induced creatinuria is related to its effect on the blood creatine concentration, rather than to an effect on the kidneys per se.
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