Abstract
Summary
Spontaneous ischemia of the kidney has been reported in dogs subsequent to anesthesia and/or surgical trauma. This phenomenon can be characterized as having a differential effect on intrarenal aerobic metabolism. Washed homogenates of cortical and medullary tissue were prepared from nonischemic and ischemic kidneys. The rates of O2 consumption, α-KG utilization, and P 1 disappearance were the same in cortical homogenates of ischemic and nonischemic kidneys. Each of these rates was significantly lower in medullary homogenates of ischemic kidneys than in nonischemic kidneys. Cortical homogenates that were stressed secondarily by acute aging had rates of O2 consumption, α-KG utilization, and P 1 disappearance that were below that of fresh homogenates. The changes in metabolism cannot be explained by changes that were observed in the activities of MDH and ICDH.
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