Inhibition of RNA Synthesis in Mammalian Cells by Pentobarbital Sodium 1

Abstract

Summary

Pentobarbital inhibits the incorporation of ³²P and sodium formate-¹⁴C into RNA of Ehrlich ascites tumor cells in vivo and in vitro. In addition, the RNA specific activity of Ehrlich ascites cells prelabeled with uridine-³H, remains constant in untreated cells and in cells treated with pentobarbital, but decreases in cells treated with actinomycin D or with actinomycin D plus pentobarbital.