Abstract
Summary and Conclusions
The effect of chlorothiazide on renal blood flow was assessed in conscious dogs in which flow transducers and pressure cannulas were chronically implanted. The results show that chlorothiazide (5 mg/kg, intravenously) increased renal vascular resistance and consequently decreased renal blood flow. It appears that a small drug-induced increase in renal vascular resistance can produce a rather substantial decrease in renal blood flow. It also appears that conscious animals may be more susceptible to the renal vasoconstricting action of the thiazides than anesthetized animals. The drug-induced decrease in renal blood flow lasted less than 30 min whereas the drug-induced increase in sodium excretion was still near maximal at 60 min.
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