Abstract
Summary
Several short-chain aliphatic carbonyl compounds inhibited anaerobic metabolism in rabbit lenses. A very potent inhibitor, glycolaldehyde, inhibited lactic acid production and glucose utilization and lowered labile phosphate in the lens. Glycolaldehyde had no appreciable effect on the transport of glucose into the lenses. The effect of glycolaldehyde may have been a direct one or may have occurred through its metabolism to inhibitory oxidation products in the lenses. Glyoxylate and glycollate could not account completely for the inhibitory effects of glycolaldehyde in either intact lenses or in lens homogenates.
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