In Vitro Association of Iodide and Thyroidal Lipids

Abstract

Summary

Evidence is presented to show that enhancement of iodide solubilization in a nonpolar organic solvent in equilibrium with water, is due to micellar formation and that the lipid-iodide binding is ionic in nature. The enhancement of ¹³¹I solubility in chloroform by the addition of Fe³⁺ was shown to be due to oxidation of iodide to iodine, a reaction which could be prevented by addition of PTU to the in vitro system. In the presence of thyroidal lipids, the iodine formed was subsequently bound to the lipids covalently.