Abstract
Summary
The chronological events occurring in blood after intoxicating doses of ammonium carbonate were studied using the suckling pig. Physical manifestations included vomiting, hyperventilation, hypersensitivity to sound, convulsions, and tetany followed by death in some cases. Blood glucose, dihydroxyacetone-P, pyruvate and lactate were raised indicating failure to decarboxylate pyruvate. Elevated blood ketone bodies indicated increased fat catabolism as a result. Consistent rise in blood pentose may either be due to an inhibition of the pentose phosphate pathway or an increased metabolism of glucose via this pathway to make up for reducing power lost through impairment of the TCA cycle.
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