Abstract
Summary
Intestinal secretion fluid from donor rabbits experimentally infected with V. cholerae was sterilized by filtration. The nitrate was administered intraluminally to ligated small-intestinal loops of recipient rabbits. The volume of fluid accumulating in such loops was determined at various times, filtrate dilutions, and loop positions in the jejunoileum. Effluents were analyzed for potassium and chloride content. The time course of the volume response to filtrate (undiluted and diluted 1:10) was similar to that reported for experiments with crude enterotoxins prepared in vitro, as were mean effluent potassium and chloride concentrations. Regional variations in effluent volume and composition were not evident. Effluent chloride content increased substantially with time.
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