Abstract
Summary
Experiments in hypophysectomized rats indicated that though growth hormone and aldosterone could produce summative antinatriuresis when given together, neither growth hormone nor the hypophysis appeared necessary for aldosterone to exert a profoundly antinatriuretic effect. Previous dietary history, however, may modify the response of the hypophysectomized rat to aldosterone. In sodium-replete rats, the response was antinatriuretic and antidiuretic, while in sodium-depleted rats, the response was diuretic and did not significantly modify sodium excretion.
Special thanks are rendered to Dr. I. S. Edelman who suggested some of the experiments herein reported. The excellent technical assistance of Mrs. Lucy Moore is appreciated.
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