Abstract
Summary
At 5, 7, 9, and 11 ATA of 100% O2: Cysteine + succinate offers the greatest protection against O2 toxicity. Succinate is the most effective single compound for protection against O2 toxicity. The failure of GSH to sustain its degree of protection at 7, 9, and 11 ATA is thought to be due to insufficient time available to permit conversion of GSH to succinate due to the increased severity of stress. The acid-base buffer, Tris, was less effective at 7, 9, and 11 ATA than -SH group protectants. Malate, a NAD-linked substrate offers no protection against O2 toxicity.
We thank Marvin and Julie Nunn for valuable technical assistance.
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