Abstract
Summary
Pouches were prepared from the proximal duodenum in mongrel dogs and intravenous infusion of glucagon caused dose related increases in the volume of secretion from these pouches. The maximal response, 1.4 ml/15 min, was produced by a glucagon dose of 64 μg/kg-hr. Glucose infusions did not stimulate Brunner's gland secretion, indicating that the hyperglycemic effect of the glucagon was not responsible for the increase in duodenal secretion. Oral glucose administration also failed to stimulate Brunner's gland secretion.
This work was supported by a Veterans Administration Clinical Investigator appointment (R.S.J.). The authors gratefully acknowledge the technical assistance of Elizabeth Stevenson. Dr. K. Jan Bossart kindly assisted in the surgical preparation of the animals used in this study. A portion of the glucagon used in this experiment was supplied by the Eli Lilly Company.
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