Abstract
Summary
The mechanism of the blood pressure fall produced by ellagic acid was evaluated. Pretreatment of rats with diphenhydramine hydrochloride, compound 48/80, or dextran significantly reduced the blood pressure fall caused by ellagic acid. These results suggest that histamine is involved in producing the blood pressure fall following ellagic acid administration. The latency period (20–30 sec) before the blood pressure fall, and the blockade effect of ellagic acid on the effect of a second dose of ellagic acid suggest the release of histamine by this compound. Effects of acetylcholine, norepinephrine, epinephrine, and histamine (on blood pressure) administered intravenously were not significantly changed after the rats received ellagic acid.
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