The Effect of Methyl Acetylsalicylate on Renal Tubular Ionic Reabsorption 1

Abstract

Summary

The effect of methyl acetylsali-cylate on renal tubular ionic reabsorption was studied by clearance experiments in dogs. The compound produced a significant decrease in the rates of excretion of Na⁺, Ca²⁺, Mg²⁺, CI^-, and HCO₃ ^-. As this occurred despite an increased filtered load of the various ions, it was concluded that methyl acetylsalicylate increased tubular ionic reabsorption. One mechanism causing increased reabsorption was a decrease in RPF. However increased ionic reabsorption was demonstrable in the absence of falling RPF. Thus a second mechanism appeared to be involved, namely a direct action of the compound on the tubular epithelial transport mechanisms.