Abstract
Summary
Immunization of mice with parainfluenza viruses NDV or Sendai increases the oncolytic effect of these viruses when pre-infected leukemic cells are injected into C3H mice. Variations in oncolytic activity between different strains of influenza and parainfluenza viruses were noted, and also between two leukemic tumors induced by the Gross virus. Statolon given before virus-infected cells prevents oncolysis but has no effect when given later. Antiserum to NDV or Sendai (plus complement) shows a cytolytic effect in vitro against leukemic cells infected with these viruses.
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