Abstract
Summary
Eight to ten weeks after implantation of a functional pituitary tumor, MtT/F4 (Furth), into young male Fischer strain rats the following ratios were increased in relation to controls: Liver weight and plasma volume per gram body weight, the rate of albumin synthesis and the total microsomal RNA per liver, and the microsomal RNA per gram liver. However, the albumin concentration per milliliter plasma, the rate of albumin synthesis per gram liver or per milligram microsomal RNA were decreased. It is concluded that in rats with MtT the ribosomal units are less effective in albumin synthesis, but that the total amount of albumin synthesized is larger because of the considerable increase in liver size and total microsomal RNA. The effect of MtT on the function of the endoplasmic reticulum is discussed.
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