Abstract
Summary
Effects of antithymus serum and antilymphocyte serum on the spontaneous incidence of lymphoid leukemia in AKR mice were studied. Treatment of AKR mice with normal rabbit serum or antirat-lymphocyte serum which has no lymphopenic or immuno-suppressive effects in the mice seems to delay death of the mice due to spontaneous lymphoid leukemia. Despite or, perhaps, because of their lymphopenic and immunosuppressive effects in the mice antirat-thymus serum, antimouse-thymus serum and antimouselymphocyte serum failed to alter the incidence of lymphoid leukmeia. Prolonged mean survival ages in the mice treated with either normal rabbit serum or antirat-lymphocyte serum might be attributed to their nonspecific stimulatory effects on immune responses.
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