Abstract
Summary
Subcutaneous administration of desoxycorticosterone acetate (DOCA) to adrenalectomized rats at 50 and 100 μg/100 g of body weight/day reduced their spontaneous NaCl intake significantly. When hydrochlorothiazide (HCZ, 0.6 g/kg of food) was administered concurrently, the effect of DOCA was prevented and NaCl intake increased. The HCZ also increased the NaCl intake of untreated adrenalectomized rats. Hence, the presence of adrenal steroids is not required for this response. The results suggest that increased intake of NaCl solution by HCZ-treated, adrenalectomized rats may be related to increased urinary excretion of sodium. However, the mechanism by which increased sodium loss may mediate increased sodium intake requires elucidation.
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