Abstract
Summary
The Moloney strain of mouse sarcoma virus (MSV) enhances the replication of mouse hepatitis virus (MHV) in Balb/c mouse embryonic fibroblasts (MEF Balb/c). This enhancing effect may explain in part the unusual spread of MHV in leukemic mice, as often reported in the literature. This stimulating effect was induced by the MSV genome and seems to be related to a new protein produced by the cells. The data here presented support the hypothesis that this stimulating activity was related to a blocking effect of this protein on the biological action of interferon, comparable to the stimulons previously described for adenoviruses. In vivo MSV appeared to be resistant to highly potent interferon preparations, in vitro it diminished the titer of exogenous interferon. MSV had no detectable effect on the production of interferon in MEF Balb/c cells by Newcastle disease virus (NDV).
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