Abstract
Summary
A culture variant of S. malayensis elaborates a metabolite (mitomalcin) which displays striking activity against Leukemias L-1210 and P-388 when administered intraperitoneally in single, daily, and interrupted dosage schedules. The purified protein is active in vitro against common gram-positive microorganisms and is approximately 30-fold more cytotoxic to the HeLa cell than to a normal mouse embryo cell line.
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