Abstract
Conclusions
The effectiveness of intraperitoneal grafts of thymus and other tissues was tested by observing their ability to restore to neonatally thymectomized C57BL/6 mice their ability to reject the Walker 256 carcino-sarcoma of rats. Grafts of isogeneic thymic tissue, both free and in cell-impermeable Millipore chambers, were effective. Grafts of isogeneic splenic tissue from 14-day-old mice were effective if transplanted free but not if enclosed in Millipore chambers. Free grafts of splenic tissue from neonatally thymectomized mice were ineffective. Free grafts of isogeneic duodenum, lung, liver, kidney, skeletal muscle, and submaxillary and thyroid glands were ineffective. Free grafts of xenogeneic thymus tissue from Sprague-Dawley rats, either neonatal or 14 days of age, were effective. The effectiveness of thymic grafts in this model increased as the mass of tissue transplanted was increased and was independent of the finding of histologically normal thymic tissue at the end of the period of observation.
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