Abstract
Summary
Platelets were collected from healthy and diseased subjects and platelet alkaline phosphatase (PAP) was measured and compared to the patient's leukocyte alkaline phosphatase (LAP). Seven out of eight patients with a myeloproliferative disease had PAP levels varying from normal by more than 2 standard deviations. Seven out of the eight patients also had an abnormal LAP, however, the LAP and PAP varied independently. Three out of the three patients with an infectious leukocytosis had a normal PAP while the LAP was elevated. This strongly suggests that there is no single mechanism for control of alkaline phosphatase in myeloid cells.
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