Abstract
Summary
Adult male Sprague-Dawley rats were subjected to acute anoxia of 6-min duration in an environment of purified nitrogen containing 30-40 ppm of oxygen. Six tissues, namely, the heart, kidney, liver, pancreas, parotid, and submandibular gland, were analyzed with respect to the changes in succinate and lactate dehydrogenase activities caused by anoxia. The results show that, while both enzyme activities are suppressed in the organs studied, SDH activity was most suppressed in the heart, kidney, and pancreas. On the other hand, the submandibular gland showed a significant increase in LDH activity. These results support the view that the reduction of protein synthesis in different organs following exposure to anoxia is variable.
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