Abstract
Summary
Rat virus has been shown to be infective for BALB/c mice after intracerebral inoculation of newborn animals. Infective virus was recovered from either brain or pooled liver and kidney tissue, with maximal titers of >6 logs being present in the brain 6-8 days after infection. Mice infected with large amounts of RV showed a high incidence of overt disease which took the form of either (a) an acute fatal syndrome occurring 4-8 days after inoculation, or (b) marked dwarfism in survivors. Other survivors remained free of symptomology, but reacted to secondary challenge in a manner suggesting they might carry an inapparent infection. The significance of these findings is discussed.
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