Abstract
Summary
Seven dogs were prepared with completely separated vagally denervated antral pouches, gastrojejunostomy, and cholecystectomy. A duodenal cannula was placed opposite the opening of the common bile duct in each animal. In 3 of these dogs, a Heidenhain pouch was also constructed whereas in the other 4 animals a gastric cannula was placed in the ventral wall of the stomach. Biliary volume and composition were studied by catheterization of the common bile duct during constant i.v. infusion of 2% sodium taurocholate to maintain an intact enterohepatic circulation of bile salts. In the dogs with Heidenhain pouches or when the gastric cannula was closed, perfusion of the antral pouch with buffered 4% choline chloride solution at pH 7.5, caused highly significant increases in biliary volume, HCO3 concentration and output, Cl concentration and output and total outputs of Na, K, bile salts, and bile solids. The concentration of Na and K was unchanged but the concentration of bile salts and solids was decreased. When the gastric cannula was opened, none of these effects were observed and there were no significant changes from the control values in biliary volume or composition. These studies indicate that the effect of endogenous gastrin on hepatic bile flow during artificial maintenance of the enterohepatic circulation of bile salts is predominantly an indirect one resulting from the entrance of acid into the small intestine.
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