Abstract
Summary
Surgical reduction of the mass of a clipped kidney does not alter the course of hypertension, whether a contralateral untouched kidney is present or not, while subsequent removal of the clip or excision of the kidney usually causes remission of hypertension. These observations do not support the view that hypertension is due to an imbalance between flow and mass, which can be corrected by reduction of renal mass. Constriction of the clipped kidney by a ligature causes a gradual renal atrophy and remission of hypertension only when the contralateral kidney is present. There is no relationship between renal renin and pressure levels.
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