The effect of exercise on the blood sugar of depancreatized dogs

Abstract

Blood sugar curves of dogs made to run on the treadmill one to four days after extirpation of the pancreas showed:

1. That after 20 to 30 minutes of such exercise, in animals which were being fed 200 grams of meat and bread daily, there occurred a fall in the amount of reducing substance in the blood, sometimes amounting to as much as 100 mgm. per 100 c.c.

2. That in starved animals such exercise caused a rise in the amount of reducing substance in the blood, amounting in one case to 85 mgm. per 100 c.c. during 30 minutes of exercise.

The conclusions suggested by these results are that, even after complete extirpation of the pancreas the power of sugar consumption is not entirely lost, and that there may be a difference in the power of such animals to utilize sugar according as it is derived from tissue proteins or by absorption from the intestinal tract.