Abstract
Summary
The appearance and kinetics of antibody-producing spleen cells was demonstrated after use of S. typhosa, strain 0901, and S. paratyphi A as immunizing antigens and as indicators in a bacteriolytic (or bacteriostatic) plaque assay in agar. The results showed that in the very beginning of the immune response antibody-producing cells appeared which were able to produce mainly antibodies against the XII antigens which are present in both S. typhosa and S. paratyphi A. The number of plaques was dependent on the sensitivity of the strain employed for the assay; the highly sensitive strain 0901 produced higher numbers of plaques in the presence of homologous antibodies and also in the presence of anti-S paratyphi A anti-bodies than the S. paratyphi A strain. No significant differences were found in the response to living and to heat-killed bacteria.
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