Intestinal Absorption of Heparin in the Rat and Gerbil

Abstract

Summary

When heparin was administered intraduodenally in an emulsified form to rats and gerbils, a marked increase in clearing factor and anticoagulant activity was obtained. Vegetable oils were more effective than mineral oil, suggesting that an oil susceptible to lipolysis is necessary for activity. A number of emulsifying agents have been shown to be effective. Mactin B, a polysaccharide obtained from the clam, similar to heparin but of greater molecular weight, was not absorbed when introduced into the duodenum in an emulsified form.