Abstract
Summary and conclusions
In this experiment, hypertension was produced by a series of starvation-refeeding periods. Capacitance of the arterial system of swine, in vivo, was investigated by a pulse wave analysis. Changes in capacitance of the arterial system of swine were determined by a comparison of swine which had undergone a series of starvation-refeeding periods with animals on a normal, uninterrupted diet. A decreased capacitance (p < 0.001) was found in the arterial system of swine which had undergone a series of starvation-refeeding periods.
Arterial blood velocity estimates were made for all swine and an increased arterial blood velocity was found in starved-refed swine which had decreased capacitance. Cardiac output was determined simultaneously with arterial pressure recordings. Results from this work indicate that decreased capacitance of the arterial system in swine is the factor responsible for diastolic hypertension in starved-refed swine.
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