Abstract
Summary
Mechanisms leading to the natriuresis following the intravenous infusion of saline were studied by loading dogs with equal volumes of physiological saline and autologous blood. Blood given in a volume equal to 5% of body weight and 10 ml/min produced cardiovascular deterioration although a similar volume of saline was tolerated. Both saline and blood in smaller volumes produced a natriuresis; however, the increase in sodium excretion was greater after saline than blood. The naturiuresis after saline loading occurred even in those experiments in which glomerular filtration rate was reduced, whereas after blood loading a decrease in the rate of filtered sodium was associated in two experiments with a decrease in sodium excretion. It is suggested that the lesser response to blood was due at least in part to elevated renal venous pressure.
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