Anti-Inflammatory Activity of 2,4-Dinitrophenol following Local Administration at the Site of Inflammation

Abstract

Summary

2,4-Dinitrophenol was tested for local anti-inflammatory activity at the site of inflammation using the carrageenin-induced paw edema as an experimental model of inflammation. This compound was active only at or near lethal doses. Although dinitrophenol, compared to phenylbutazone, appears to be a more potent uncoupler of oxidative phosphorylation in vitro, it was less active on a milligram basis as an anti-inflammatory compound against the carrageenin-induced paw edema when administered locally at the site of inflammation.