Abstract
Summary
Cholesterol in amounts of 50-500 μg/ml when mixed in vitro with supernates of enteric bacteria, containing both common enterobacterial antigen (CA) and lipopolysaccharide (endotoxin), increases the immunogenicity of CA upon intravenous injection into rabbits. Enhancement of the antibody response does not occur when supernate and cholesterol are injected separately, albeit simultaneously. Since cholesterol does not enhance the antibody response to the isolated, ethanol-soluble CA, it is suggested that the effect of cholesterol on the immune response is due to inhibition of the immunosuppressive lipopolysaccharide.
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