Abstract
Summary
Mean effective doses (50% protection) of S. typhimurium heat-killed, alcohol-treated bacterial vaccine depended upon the interval before challenge at which the single dose was given. Circulating antibody response against the lipopolysaccharide component of the organism appeared to be related to the magnitude of the mean effective dose, but not to the partial immunity developed. Killed vaccine was an effective immunizing agent if given at an optimal time interval before challenge.
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