Abstract
Summary
The renal tubular transport of 3-O-methyl-D-glucose (3MG) was studied in dogs and rats. The 3MG was found to be actively secreted by a phlorizin sensitive mechanism in dogs. The nature of the renal handling of 3MG in rats was found to be different from that found in dogs, since, 3MG was reabsorbed by the renal tubules of rats at a rate of about 10% of the 3MG filtration rate. This was interpreted as a result of a reabsorptive process having a larger magnitude than a simultaneously operating secretory process for the same compound. The secretion of 3MG in dogs was found to occur in the proximal tubules and was not inhibited by 2,4-DNP. It was significantly augmented by an intravenous infusion of D-glucose. The results of these experiments were taken as evidence for the existence of a bidirectional sugar transport system in the renal tubules of dogs. This system would be capable of reabsorbing D-glucose and also capable of secreting 3MG and L-glucose.
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