Abstract
Summary
In beagles 6-9 days old, hydrocortisone sodium succinate (5—150 mg/kg), given intravenously 1 hour before intravenous lethal doses (2 mg/kg) of E. coli endotoxin, increased the rate of survival, and, in some animals, the duration of survival; the effect of hydrocortisone was not dependent on the dose given. Hydrocortisone (50 mg/kg) given immediately after endotoxin (0.1—2 mg/kg) did not increase the rate or duration of survival.
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