Abstract
Summary
Administration of triamcinolone in the hyperlipemic diet of rats for a 4-week period, at dosages little affecting the body weight, afforded a marked protection against the large and multiple phlebothromboses initiated in these rats by the intravenous injection of a S. typhosa lipopolysaccharide. As in acute experiments, this protection could be related to a marked increase in the plasma clotting time, the percentage of α lipoproteins and of albumin. Independently of its protective effect on thrombosis, triamcinolone, at a low dosage, seemed to decrease the cholesterol levels, while it increased them at a higher dosage. However, there was no significant changes in the serum triglycerides.
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