Abstract
Summary
The platelet aggregation induced by purified repolymerized collagen fibers is inhibited by D-glucosamine: this inhibitory effect requires a preincubation of glucosamine with tropocollagen during the polymerization of the fibers. Weak inhibition was obtained when glucosamine was added to the polymerized fibrils or to the platelets. This phenomenon seems to depend on a specific modification of the collagen fibrils polymerized in the presence of glucosamine.
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