Abstract
Summary
Rates of absorption of ethanol, thiopental and salicylic acid by pouches of the canine oxyntic glandular mucosa were measured when the pouches were unstimulated and not secreting and when they were strongly stimulated to secrete by injections of histamine and gastrin pentapeptide. No differences were found between the 2 situations when rates of absorption were referred to the mean concentrations of the compounds in the fluid contained in the pouches. It is concluded that the high rate of flow of water out of the mucosa when it is stimulated to secrete does not reduce the rate at which substances can diffuse passively into the mucosa, and it is further concluded that the tubules of the gastric glands in which the rate of flow of water is greatest are not an important site of absorption.
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