Abstract
Summary
Murine Sarcoma Virus (Moloney) rarely induces tumors in intact newborn rats. When rats were thymectomized at birth and infected within 2-3 days, 30 to 50% of infected thymectomized rats developed tumors. One of the transplantable tumors established in tissue culture is found to be free of infectious virus. It possesses tumor specific antigen as demonstrated by transplantation resistance tests. Furthermore the defective sarcoma viral genome can be rescued either by superinfection of a mixed culture of tumor cells and mouse embryo cells with leukemogenic viruses or by direct super-infection of tumor cells. It is now possible to assay the rescuing-activity quantitatively with given preparation of leukemogenic virus.
Get full access to this article
View all access options for this article.