Abstract
Summary
Live Mycobacterium tuberculosis injected intravenously into rabbits produced higher titers of hemagglutination (HA) and hemagglutination lysis (HL) antibodies than were obtained using phenol-killed or heat-killed M. tuberculosis. In guinea pigs, injection of 106 cells of M. tuberculosis, either intracardially or intraperitoneally, resulted in HA or HL antibody, whereas antibody was not produced by animals injected with lower doses. HA or HL antibody was not produced by subcutaneous injection of live organisms.
Serum obtained from guinea pigs three weeks after intracardial injection of M. tuberculosis strain H37Rv was used to determine the immunoglobulin class of antibody responsible for the HA and HL reaction. Only 19S immunoglobulin could be associated with this antibody activity.
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