Abstract
Summary
The dose-response pattern of the submaxillary gland of the dog to pilocarpine was studied using the sialogram. Following the administration of each dose of pilocarpine, salivary flow rate rose to a peak in one to four minutes and then declined. Duration of the secretory response was directly related to dose. Rate of flow, however, was directly related to dose up to an optimal secretory dose. Doses higher than this caused the flow rate to decline. A study of the salivary flow and pressure changes showed that the decline is related to an increase in salivary viscosity.
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