Abstract
Summary
The phospholipids of the diaphyseal and metaphyseal portion of the long bones of rats have been analyzed. Lecithin, phosphatidylethanolamine, sphingomyelin and lysolecithin constitute the major phospholipids with small amounts of cardiolipin and phosphatidic acid also being present. Hypervitaminosis D was found to cause a significant increase in all phospholipids without a selective action on any one component. The incorporation of P32 into the phospholipids was found to be increased indicating an increased synthesis rather than a decreased break-down. It is suggested that the accumulation of lipid material may be related to the failure of the osteoid in hypervitaminosis D to calcify properly.
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