Abstract
Summary
Exposure of young, adult rats to electric shock resulted in a significantly elevated level of blood histamine. The pattern of response was related to the animal's sex and pre-shock environment. Females were more sensitive to noxious stimulation than males, as reflected in a more rapid increase and subsequent fall in circulating levels. Post-weaning group living, compared to isolation, was associated with both greater sensitivity and a more pronounced total response. Infantile-manipulated rats had a numerically greater sensitivity and total response, in comparison with non-manipulated controls.
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