Abstract
Summary
Paired experiments were performed to determine whether saline infusion produced an effect different from the effect of isoncotic albumin in saline. The results obtained indicate that for equal volumes of infusion delivered at identical rates, saline infusion provides a greater stimulus to the excretion of sodium than isoncotic albumin in saline. During the earlier phase of infusion the diminished response to isoncotic albumin in saline may be related to both the maintained oncotic pressure and a rising venous pressure. As the infusion of isoncotic albumin in saline is continued, after a period of stabilization, the rate of sodium excretion declines and then appears to correlate with a continuing increase in venous pressure.
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