Abstract
Summary
The results from the present study with orally administered 3-(p-chloro-phenoxy) − 2 -me thoxypr opyl carbamate (M CC) in rats indicate that the absorbed drug was completely demethylated in vivo since no metabolites with intact methoxyl groups were detected. The principal urinary metabolite in the rat was chlorphenesin carbamate O-glu-curonide; however, a significant portion of the MCC or its metabolites also were dealkylated in vivo to yield p-chlorophenol. In addition, no evidence for formation of an N-glucuronide conjugate was obtained. In vitro studies have shown that while cleavage of the methoxyl group of MCC or its metabolites can take place in liver microsomes, the enzymatic hydrolysis of the aryl-alkyl ether linkage of MCC probably occurs at some other site.
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