Abstract
Summary
Red cell content in liver was measured in normal and in shocked dogs using two independent methods of measurement. The mean concentration of red cells in the liver of a series of dogs under control conditions was 0.027 ± 0.002 (SE) ml/g liver tissue. After hypovolemic shock and retransfusion of the shed blood, the red cell content in liver tissue increased to an average of 0.052 ml/g. Under control conditions, the red cell label of peripheral blood was mixed adequately with the red cells in liver tissues. After shock, differentially labeled red cells mixed more slowly with the red cells in the liver and in some instances did not become equilibrated during the course of the experiments. This suggests a pool of noncirculating or slowly circulating red cells in the liver after shock. These changes may affect adversely the precision and interpretation of blood volume measurements made by conventional techniques and sampling schedules.
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