Abstract
Summary
Histoplasmins from two strains of Histoplasmia capsulatum have been fractionated by salting-out and electrophoretic procedures. Fractions obtained in this manner have been assayed for ability to induce a delayed type of hypersensitivity in sensitized guinea pigs. Carbohydrate-rich fractions appear to be more effective in this regard, and one histoplasmin fraction has been found which exhibits no precipitin activity but is highly effective in the skin test. The skin test reaction with histoplasmin is also demonstrated to be an example of a delayed hypersensitivity reaction.
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