Abstract
Summary
The exaggerated natriuretic response to infusion of saline observed in hypertensive man or dog might be related to vaso-constriction within some key organ rather than to elevation of blood pressure. To examine this thesis saline infusion was administered to 16 mongrel dogs while individual organs were perfused with suppressor doses of metar-aminol. The dose of metaraminol was that which the organ would receive during a systemic pressor infusion known to result in exaggerated natriuresis in the dog. The local pharmacologic effects of metaraminol on kidney, liver or brain did not result in an augmented natriuretic response to the infusion of saline. These data are therefore consistent with the view that hypertension itself is necessary for the appearance of exaggerated natriuresis in response to saline infusion in the dog.
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